FHIR Works on AWS is a new AWS Solutions Implementation with an open source software toolkit that can be used to create a Fast Healthcare Interoperability Resources (FHIR) interface over existing healthcare applications and data. It uses a serverless implementation to provide FHIR APIs that support the majority of FHIR resource types and operations. FHIR Works on AWS also includes architecture patterns for designing and building integrations to existing systems. Independent software vendors, system integrators, and healthcare providers can use the solution to improve access from mobile devices and web portals with standard FHIR APIs. Finally, the solution includes guidance on how to customize the default FHIR Works on AWS API to an organization’s specific needs.